I am so impressed that they continue with writing. There have been near misses along the way, meetings with agents and publishers that have looked promising but haven't ended up in a contract, lots of positive rejections and so on. It's always a bit tricky offering advice because I don't want to appear patronising and besides, my choices are not necessarily paths they would choose to take. The only thing is...
It occurred to me that when I was looking for an agent I sent my work out to more agents than all of them together have done over the past ten years. And yes, it's tiring and yes, it can be hard to motivate yourself after yet another rejection, but I can't help thinking that if you're serious about getting published you have to get out there: it won't come to you.